By Vitamin B12 deficiency in both paternal and maternal sides has a programming effect on the DNA which affects the next generation of offspring and increases the risk for cardiometabolic syndrome in a sex-specific manner, Dr Shantanu Sengupta, Senior Principal Scientist at New Delhi-based CSIR-Institute of Genomics and Integrative Biology, said here today.
Delivering the keynote lecture at a national symposium on ‘mass spectrometry-based lipidomics’ at Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Dr Sengupta said his study was based on the multi-omics approach that helps analyze multiple types of molecular information within individual cells to gain a more comprehensive understanding of cellular behaviour and function.
He also mentioned about an initiative ‘Phenome India’, a large longitudinal study involving over 10,000 people aimed to develop a clinically useful, personalized risk prediction scores for complex cardio-metabolic disorders that affect the heart, blood vessels, and metabolism. These include heart disease, stroke, diabetes, and non-alcoholic fatty liver disease.
It is a robust, accurate and precise biomarker panel for screening populations at higher risk of cardiovascular disease, he pointed out.
Dr S Asha Nair, Scientist and Dean, RGCB, inaugurated the symposium. Dr Abdul Jaleel, Organizing Secretary, welcomed the gathering.
Delegates from different parts of the country are attending the two-day conference.
